Scientific publications

Here you find a number of scientific publications in the field of molecular pathways, stem cell research and cancer treatment from the participants.

Apidianakis Y, Grbavec D, Stifani S, Delidakis C. Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch. Development. 2001;128:4361-70.

Bejarano F, Perez L, Apidianakis Y, Delidakis C and Milan M 2007. Hedgehog restricts its expression domain in the Drosophila wing. EMBO Reports 8, 778-783.

Benitah S A, Frye M, Glogauer M, Watt F M. Stem cell depletion through epidermal deletion of Rac1. Science. 2005;309:933-5.

Callejo A, Culi J, Guerrero I. (2008). Patched, the receptor of Hedgehog, is a lipoprotein receptor. PNAS 2008;105 (3); 3912–917.

Callejo A, Torroja C, Quijada L, Guerrero I. Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix. Development. 2006;33(3): 471-83.

Clement et al. HEDGEHOG-GLI signalling regulates human glioma growth, cancer stem cell self-renewal and tumorigenicity. Curr Biol. 2007;17:165-72.

Di Marcotullio L, Gulino A et al. Numb is a suppressor of Hedgehog signaling and targets Gli1 for Itch-dependent ubiquitination. Nature Cell Biology. 2006;8:1415-1423.

Eichberger T, Kaser A et al. GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells. J. Biol. Chem. 283(18):12426-37.

Ferretti E, --- Gulino, A. Concerted microRNA control of Hedgehog signaling in cerebellar neuronal progenitor and tumor cells. EMBO J. 2008 in press.

Gorfinkiel N., Sierra J, Callejo A, Ibanez C, Guerrero I. The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog. Dev Cell. 2005;8(2): 241-53.

Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, Clevers H, Toftgård R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nature Genetics, article in press, 2008.

Jensen K B and Watt F M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc. Natl. Acad. Sci. USA. 2006;103:11958-63.

Kasper M, Aberger F et al. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes. Mol Cell Biol. 2006;26(16):6283-98.

Lauth M, Bergström A, Shimokawa T, Toftgård R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60.

Morita K, Lo Celso C, Spencer-Dene B, Zouboulis C C, Watt F M. HAN11 binds mDia1 and controls GLI1 transcriptional activity. J. Dermatol. Sci.. 2006;44:11-20.

Palma et al. Sonic hedgehog controls stem cell behaviour in the postnatal and adult brain. Development. 2005;132:335-44.

Pitsouli C and Delidakis C 2005. The interplay between DSL proteins and ubiquitin ligases in Notch signaling. Development 132, 4041-4050.

Regl G, Aberger F et al. Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res. 2004;64:7724-31.

Stecca B, et al. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci U S A. 2007; 104:5895-900.

Svärd J, Toftgard R et al. Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell. 2006;10(2):187-97.


In Science Signaling published presentations from the 1st International HEALING Meeting: Hh-Gli Signaling in Development, Regeneration and Disease, Kolymbari, Crete, 23 to 25 June 2011.

Ariel Ruiz i Altaba*. Hedgehog Signaling and the Gli Code in Stem Cells, Cancer, and Metastases. Sci. Signal. 2011;200:9.

Ariel H. Polizio, Pilar Chinchilla, Xiaolen Chen, David R. Manning, and Natalia A. Riobo*.Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins. Sci. Signal. 2011;200:7.

Sougata Roy and Thomas B. Kornberg*. Direct Delivery Mechanisms of Morphogen Dispersion. Sci. Signal. 2011;200:8.


* Presenter and corresponding author